Relationship between serum cystatin C and serum adiponectin level in type 2 diabetic patients.

Background: To investigate the relationship between serum levels of cystatin C and adiponectin in patients with type 2 diabetes. Methods: We examined serum cystatin C and adiponectin levels in 234 patients with type 2 diabetes who visited our hospital. Results: The serum level of cystatin C was positively correlated with age ( P < 0.001), duration of diabetes ( P = 0.013), serum creatinine ( P < 0.001), uric acid ( P < 0.001), and adiponectin (p = 0.001), while it was inversely correlated with estimated glomerular filtration rate ( P < 0.001). Serum adiponectin was significantly higher in patients with high serum cystatin C levels than in those with normal cystatin C levels (8.3 ± 4.7 and 6.2 ± 3.2 μg/mL, respectively; P < 0.001). Adiponectin was also significantly higher in male patients with high cystatin C levels, but not in females. In multiple regression analysis, serum adiponectin was also independently and significantly correlated to age, diastolic blood pressure, high-density lipoprotein cholesterol, triglyceride and serum cystatin C. Conclusions: Serum adiponectin level was correlated with serum cystatin C level on simple and multiple regression analyses in patients with type 2 diabetes. Although circulating adiponectin is increased in advanced kidney disease, it might be biologically inactive due to binding to cystatin C and thus not display an anti-arteriosclerotic effect. [ABSTRACT FROM AUTHOR]