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Isolation, crystal structure, and cytotoxicity on osteosarcoma of a ruthenium(III) complex with coordinated acetonitrile.
- Source :
-
Journal of Coordination Chemistry . Jul2012, Vol. 65 Issue 14, p2489-2499. 11p. 1 Color Photograph, 2 Diagrams, 2 Charts, 2 Graphs. - Publication Year :
- 2012
-
Abstract
- The precursor Ru([9]aneS3)(DMSO)Cl2 (1), where [9]aneS3 represents 1,4,7-trithiacyclononane, was dissolved in acetonitrile at 50°C and stirred for several hours to assess the solvent's ability to coordinate to 1. A bis(acetonitrile) Ru(III) compound (2) crystallized as solid yellow needles upon slow evaporation of the reaction solution at room temperature. The structure of 2 was investigated in the solid state by FT-IR and single-crystal diffraction, showing it to be [Ru(III)([9]aneS3)(NCMe)2Cl]Cl2 · 2H2O (2). To assess the biological action of 2, growth-inhibition tests were carried by the MTT assay on a human tumor cell line of interest to our group, the osteosarcoma MG-63 line. Results have shown that the complex requires concentrations above 200 µmol L−1 at 72 h of incubation to display cytotoxic action on this cell line. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00958972
- Volume :
- 65
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Journal of Coordination Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 76515965
- Full Text :
- https://doi.org/10.1080/00958972.2012.696624