Proteína C reactiva de alta sensibilidad como predictor de fibrilación auricular postoperatoria.

INTRODUCTION: Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery with extracorporeal circulation. Is associated with increased morbidity and health costs. The ischemia-reperfusion event secondary to extracorporeal circulation leads to inflammation, causing myocardial damage. OBJECTIVE: The aim of this study is to determine the predictive power of high sensitivity C-reactive protein (hsCRP) in POAF. HYPOTHESIS: hsCPR predicts POAF occurrence. MATERIAL AND METHOD: An observational, analytical study, included 123 patients undergoing cardiac surgery with extracorporeal circulation at Universidad de Chile's Hospital, between 2007 and 2010. Continuous electrocardiographic monitoring was performed and plasma hsCPR measurement before surgery, 8 hours postoperatively and at discharge. We performed a multivariate regression analysis considering the known risk factors for POAF and the hsCRP. For continuous quantitative variable ANOVA-Bonferroni was used. Kaplan-Meier analysis of quartiles of hsPCR was used and Mantel-Cox log-rank test for trend test. Receiver operator curve (ROC) was performed to determine the predictive power of the hsPCR. Significance: p<0.05. RESULTS: We describe the clinical and epidemiological characteristics of patients undergoing cardiac surgery. The hsCPR was highest at 8 postoperative hours (ANOVA-Bonferroni p<0.01). The multivariate regression analysis significantly correlated with the occurrence of hsPCR and POAF (p<0.01). The higher quartile of hsCPR was associated with increased occurrence of POAF (p<0.01). The area under the ROC curve was 0.73. DISCUSSION: The postoperative hsPCR is a valuable predictor of the occurrence of POAF in the context of cardiac surgery with extracorporeal circulation. [ABSTRACT FROM AUTHOR]