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3,4 Dichloroaniline-haemoglobin adducts in humans: preliminary data on agricultural workers exposed to propanil.
- Source :
-
Biomarkers . Jun98, Vol. 3 Issue 3, p227-233. 7p. - Publication Year :
- 1998
-
Abstract
- Propanil is one of the major herbicides used on rice-paddies and is thought to produce adverse health effects through the action of its metabolite 3,4-dichloroaniline (3,4-DCA). T he feasibility of monitoring human exposure to propanil on the basis of 3,4-DCA adducts to haemoglobin (Hb) was investigated. We developed a method based on gas chromatography negative ion chemical ionization-mass spectrometry (NICI-GC-MS) to quantify 3,4-DCA released from human Hb after alkaline hydrolysis of the protein. 3,4-DCA-Hb adducts were identified in agricultural workers exposed to propanil and were detectable even 4 months after the last herbicide application. Urine samples collected at the same time had no measurable level of 3,4-DCA. 3,4-DCA-Hb adducts might be useful for monitoring human exposure to 3,4-DCA from agricultural sources. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEMOGLOBINS
*GAS chromatography
*ANIONS
Subjects
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 3
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 7614008
- Full Text :
- https://doi.org/10.1080/135475098231246