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Persistent abnormalities in lymphoid tissues of human immunodeficiency virus-infected patients successfully treated with highly active antiretroviral therapy.
- Source :
-
Journal of Infectious Diseases . 10/15/2002, Vol. 186 Issue 8, p1092-1097. 6p. - Publication Year :
- 2002
-
Abstract
- Effective highly active antiretroviral therapy (HAART) for human immunodeficiency virus type 1 is associated with virus suppression and immune reconstitution. However, in some patients, this reconstitution is partial or incomplete because CD4(+) cell counts do not increase significantly. This may be due to damage in the microenvironment of lymphoid tissues (LTs), where CD4(+) T cells reside. To test this hypothesis, LT samples were obtained from 23 patients enrolled in a prospective trial that compared 3 different HAART regimens. Analysis of LT architecture and CD4(+) T cells populations revealed abnormalities in 100% of the LT samples, especially in the follicles, with 43% showing absence, 14% showing regression, and 43% showing hyperplasia. CD4(+) T cell populations were abnormal in 16 (89%) of 18 tissue samples, with 7 (39%) of 18 decreased by >50% of normal levels. These data are consistent with the hypothesis that persistent abnormalities in the microenvironment can influence immune reconstitution and document persistent LT abnormalities with HAART not detected by measures of peripheral CD4(+) T cell count. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV-positive persons
*RETROVIRUS disease treatment
*LYMPHOID tissue
*ANTI-HIV agents
*COMPARATIVE studies
*HIV
*HIV infections
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*RNA
*T cells
*VIRAL load
*EVALUATION research
*HIGHLY active antiretroviral therapy
*CD4 lymphocyte count
*PHYSIOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 186
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 7595481
- Full Text :
- https://doi.org/10.1086/343802