Kadpolysperins A–N, lanostane triterpene acids possessing rich structure types from Kadsura polysperma

Abstract: Fourteen new lanostane triterpene acids (1–14), and five known analogues (15–19) were isolated from the stems of Kadsura polysperma. Compound 1, with a rearranged tetracyclic skeleton, is an important biogenic precursor of longipedlactone skeleton. Compounds 2–6 are members of 18(13→12)-abeo-lanostane triterpene acids. The structures of new compounds were elucidated by spectroscopic evidence. Selected compounds were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. [Copyright &y& Elsevier]