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Contribution of Multicentered Short Hydrogen Bond Arrays to Potency of Active Site-Directed Serine Protease Inhibitors.
- Source :
-
Journal of the American Chemical Society . 10/2/2002, Vol. 124 Issue 39, p11657. 12p. 20 Diagrams, 3 Charts, 1 Graph. - Publication Year :
- 2002
-
Abstract
- Investigates the contribution of multicentered short hydrogen bond arrays to potency of active site-directed serine protease inhibitors. Variation in the length of active site hydrogen bonds; Evidence of minor effect on inhibitor potency; Production of large structural manifolds of active site hydrogen bond motifs.
- Subjects :
- *SERINE proteinase inhibitors
*HYDROGEN bonding
Subjects
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 124
- Issue :
- 39
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 7549072
- Full Text :
- https://doi.org/10.1021/ja020082m