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A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening.

Authors :
Moon, Ho-Sang
Jacobson, Eric M.
Khersonsky, Sonya M.
Luzung, Michael R.
Walsh, Daniel P.
Wennan Xiong
Jae Wook Lee
Parikh, Puja B.
Lam, Jennifer C.
Tae-Wook Kang
Rosania, Gustavo R.
Schier, Alexander F.
Young-Tae Chang
Source :
Journal of the American Chemical Society. 10/2/2002, Vol. 124 Issue 39, p11608. 2p. 4 Diagrams, 1 Chart.
Publication Year :
2002

Abstract

Focuses on a novel microtubule destabilizing entity from orthogonal synthesis of Triazine library and Zebrafish embryo screening. Contribution of microtubule functionality in the design of anticancer drugs; Induction of similar morphological changes; Development of straight forward solid phase synthetic pathway.

Details

Language :
English
ISSN :
00027863
Volume :
124
Issue :
39
Database :
Academic Search Index
Journal :
Journal of the American Chemical Society
Publication Type :
Academic Journal
Accession number :
7549060
Full Text :
https://doi.org/10.1021/ja026720i