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A Novel Antioxidant Isobenzofuranone Derivative from Fungus Cephalosporium sp.AL031.
- Source :
-
Molecules . Apr2012, Vol. 17 Issue 4, p4219-4224. 6p. - Publication Year :
- 2012
-
Abstract
- Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7- methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-4 showed potent antioxidant activity with EC50 values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIOXIDANTS
*METABOLITES
*CEPHALOSPORIUM stripe
*FURANONES
*BIOLOGICAL assay
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 17
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 75144867
- Full Text :
- https://doi.org/10.3390/molecules17044219