Acremolin, a new 1H-azirine metabolite from the marine-derived fungus Acremonium strictum

Authors :: Julianti, Elin
Oh, Hana
Lee, Hyi-Seung
Oh, Dong-Chan
Oh, Ki-Bong
Shin, Jongheon
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jun2012, Vol. 53 Issue 23, p2885-2886. 2p.
Publication Year :: 2012
Abstract: Abstract: Acremolin (1), a novel modified base, was isolated from the culture broth of the marine fungus Acremonium strictum. Based on combined spectroscopic analyses, the structure of this compound was that of a methyl guanine base containing an isoprene unit. In addition, the presence of a 1H-azirine moiety is unprecedented among natural products. This compound exhibited weak cytotoxicity against an A549 cell line. [Copyright &y& Elsevier]

Subjects :: *AZIRINES
*METABOLITES
*ACREMONIUM
*MARINE fungi
*SPECTRUM analysis
*GUANINE
*MOLECULAR structure

Language :: English
ISSN :: 00404039
Volume :: 53
Issue :: 23
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 75012443
Full Text :: https://doi.org/10.1016/j.tetlet.2012.03.133

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