Back to Search
Start Over
Correlations between serial pro-gastrin-releasing peptide and neuron-specific enolase levels, and the radiological response to treatment and survival of patients with small-cell lung cancer
- Source :
-
Lung Cancer (01695002) . Jun2012, Vol. 76 Issue 3, p439-444. 6p. - Publication Year :
- 2012
-
Abstract
- Abstract: Introduction: To investigate whether decrease in the serum levels of pro-gastrin releasing peptide (ProGRP) and neuron-specific enolase (NSE) were correlated with the radiological response in patients with small-cell lung cancer (SCLC). Methods: Of the 196 patients, we retrospectively reviewed 118 patients elevated baseline levels of ProGRP and NSE prior to the initial therapy (IT) who survived for more than 1 month. The radiological response was assessed by Response Evaluation Criteria in Solid Tumors (RECIST 1.1). Results: Decrease in the serum ProGRP was strongly correlated with the decrease of the sum of the tumor diameters (SOD) before the third course (ρ =0.50) and after the fourth course (ρ =0.42) of IT. Decrease in the serum NSE was weakly correlated with the decrease of the SOD after the fourth course (ρ =0.27), but not before the third courses (ρ =0.22). In the receiver operating characteristic (ROC) curves predicting 1-year survivors, the area under the curve (AUC) for percent changes in serum ProGRP before the third course were significantly larger than those for NSE (0.714 vs. 0.527, p =0.004). Conclusions: Percent changes in serum ProGRP showed better correlation to SOD and prognostic impact than that of NSE. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01695002
- Volume :
- 76
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Lung Cancer (01695002)
- Publication Type :
- Academic Journal
- Accession number :
- 74988765
- Full Text :
- https://doi.org/10.1016/j.lungcan.2011.12.012