The interleukin-6 [sup -174] promoter polymorphism is associated with long-term kidney allograft survival.

Background. Th1-dependent effector mechanisms may be responsible for allograft rejection. Recently, interleukin-6 (IL-6) has been shown to antagonize CD4[sup +] T cells to effector Th2 cells and, in the process, differentiate them into Th1 cells. Methods. To assess the role of IL-6 in long-term allograft survival, 158 patients after first cadaveric kidney transplantation were analyzed for the biallelic [sup -174]G→C promoter polymorphism of the IL-6 gene. Results. Carriers of the [sup -174]C-allele (genotype GC/CC) had an inferior three-year graft survival (71/104 = 68.3%; P = 0.0059) with a 3.7-fold increased relative risk of graft loss compared to carriers of the [sup -174]GG-genotype (48/54 = 88.9%). The [sup -174]GC/CC-genotype retained its negative impact on graft survival when other established prognostic factors and further cytokine polymorphisms ([sup -308]TNF-α, TGF-β1 codon 10 & 25, [sup -592/-819/-1082]IL-10 and [sup +874]IFN-γ) were considered simultaneously. Conclusions. Since the clinical impact on transplant outcome seems as important as matching for histocompatibility antigens, genotyping of the IL-6 [sup -174]polymorphism may offer a new method for identifying patients at increased risk of allograft loss. [ABSTRACT FROM AUTHOR]