Back to Search
Start Over
The Rates of Abnormal Glucose Challenge Tests and Gestational Diabetes in Women Receiving 17α-Hydroxyprogesterone Caproate.
- Source :
-
American Journal of Perinatology . 2011, Vol. 28 Issue 10, p741-745. 5p. 5 Charts. - Publication Year :
- 2011
-
Abstract
- We compared the rates of abnormal 1-hour glucose challenge tests (GCT) and gestational diabetes (GDM) between women receiving 17α-hydroxyprogesterone caproate (17-P) and women who did not receive 17-P to determine if the effect varies based on the number of doses received or in a group of high-risk obese women. We performed a secondary analysis of a prospective cohort study where women with a history of a previous preterm delivery in the antecedent pregnancy followed at a high-risk clinic were offered 17-P. GCT was performed after the initiation of 17-P, and doses given prior to testing were recorded. Rates of abnormal GCT and GDM were compared between those receiving 17-P (n=67) and controls (n=140). Mean glucose values (112.4 versus 111.3, p=0.8), rate of abnormal GCT (23.9% versus 20%, adjusted odds ratio 1.45, 95% confidence interval 0.7 to 3.0), and rate of GDM (6% versus 8.6%, adjusted odds ratio 1.21, 95% confidence interval 0.3 to 4.5) were similar between groups. In this prospective study, 17-P administration to women at risk of recurrent preterm delivery did not significantly affect glucose tolerance. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GESTATIONAL diabetes
*GLUCOSE intolerance
*CHI-squared test
*CONFIDENCE intervals
*DOSE-effect relationship in pharmacology
*EPIDEMIOLOGY
*GLUCOSE tolerance tests
*PREMATURE infants
*LONGITUDINAL method
*OBESITY
*PREGNANT women
*PROGESTERONE
*RESEARCH funding
*T-test (Statistics)
*DATA analysis
*MULTIPLE regression analysis
*SECONDARY analysis
*BODY mass index
*DATA analysis software
*DESCRIPTIVE statistics
*PREGNANCY
*DISEASE risk factors
PREGNANCY complication risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 07351631
- Volume :
- 28
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- American Journal of Perinatology
- Publication Type :
- Academic Journal
- Accession number :
- 74632843
- Full Text :
- https://doi.org/10.1055/s-0031-1280854