Synthesis of 2'-(5-Chloro-2-Hydroxybenzylidene) Benzenesulfanohydrazide Schiff Base and its Anti- Ulcer Activity in Ethanol-Induced Gastric Mucosal Lesions in Rats.

The article focuses on a research in context to in vivo study of anti-ulcer activity of 2'- (5-Chloro-2-hydroxybenzylidene) benzenesulfanohydrazide schiff base against ethanol-induced gastric mucosal lesions in Sprague Dawley rats. It mentions that 2'-(5-Chloro-2 hydroxybenzylidene) benzenesulfano-hydrazide (Cl-BzSO-HAP) was synthesized, and characterized by the Fourier-transform infrared spectroscopy and Fourier transform-nuclear magnetic resonance analysis. Before the oral drug administration, Sprague Dawley rats were fasted overnight. The research concludes that the extensive form of gastric necrosis in rats induced by the absolute ethanol prevented by the administration of Cl-BzSO-HAP revealing in the form of reduced or total absence of lesions.