Potential of fungi as category I Consolidated BioProcessing organisms for cellulosic ethanol production

Abstract: Consolidated BioProcessing (CBP) can provide an important contribution to reducing ethanol production costs and moving from cellulosic feedstock to fuel ethanol tanks. Several efforts have so far been focused mainly on CBP category II engineering an ethanologen yeast or bacterium to be cellulolytic, but the limited ability of the category II CBP system for producing enzymes for lignocellulose degradation remains a challenge. As an alternative, category I CBP, aimed at engineering a cellulase producer to be ethanologenic, could be pursued, but it is still in its infancy. Some cellulolytic thermophilic bacteria have been described as potential candidates for category I CBP. However, only fungi naturally produce the needed titers of cellulases required for the complete saccharification of pretreated lignocellulose. In this review, potential of cellulolytic fungi as candidates for category I CBP is discussed. [Copyright &y& Elsevier]