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Phorbaketal A stimulates osteoblast differentiation through TAZ mediated Runx2 activation

Authors :
Byun, Mi Ran
Kim, A Rum
Hwang, Jun-Ha
Sung, Mi Kyung
Lee, Yeon Kyung
Hwang, Buyng Su
Rho, Jung-Rae
Hwang, Eun Sook
Hong, Jeong-Ho
Source :
FEBS Letters. Apr2012, Vol. 586 Issue 8, p1086-1092. 7p.
Publication Year :
2012

Abstract

Abstract: Osteoporosis arises from an imbalance between osteoblastic bone formation and osteoclastic bone resorption. In this study, we screened molecules from marine natural products that stimulate osteoblast differentiation. We found that phorbaketal A significantly stimulates osteoblast differentiation in mesenchymal cells. Increased interaction of TAZ and Runx2 stimulated phorbaketal A-induced expression of osteoblastic marker genes. The activation of ERK was important for the stimulation of differentiation because an inhibitor of ERK blocked phorbaketal A-induced osteogenic differentiation. Taken together, the results showed that phorbaketal A stimulates TAZ-mediated osteoblast differentiation through the activation of ERK. Structured summary of protein interactions: TAZ physically interacts with RUNX2 by pull down (View interaction) [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
00145793
Volume :
586
Issue :
8
Database :
Academic Search Index
Journal :
FEBS Letters
Publication Type :
Academic Journal
Accession number :
74500116
Full Text :
https://doi.org/10.1016/j.febslet.2012.03.008