Stimulation of Peroxisome Proliferator-Activated Receptors α and γ Blocks HIV-1 Replication and TNFα Production in Acutely Infected Primary Blood Cells, Chronically Infected U1 Cells, and Alveolar Macrophages From HIV-Infected Subjects.

Investigates the effects of peroxisome proliferator-activated receptor(PPAR)-γ agonists and PPARα agonist on HIV replication and tumor necrosis factor (TNF)α production in peripheral blood mononuclear cells. Inhibition of cell replication; Absence of correlation of TNFα inhibition with the quantitative decrease in HIV replication.