Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method

Authors :: Burgula, Laxmi Narayana
Radhakrishnan, K.
Kundu, Lal Mohan
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. May2012, Vol. 53 Issue 21, p2639-2642. 4p.
Publication Year :: 2012
Abstract: Abstract: Modified nucleobases and nucleic acids have found many biological and pharmaceutical applications. Here we report a microwave-directed synthesis of a variety of modified uracil and cytosine nucleobases with high yields under solvent-free conditions. The reaction yields were further improved by addition of Lewis acid. The crystal structures of 5-isopropyl-6-methyluracil and 6-phenyluracil were also determined. [Copyright &y& Elsevier]

Subjects :: *URACIL
*CYTOSINE
*MICROWAVES
*NUCLEIC acids
*ORGANIC solvents
*CHEMICAL reactions
*CRYSTAL structure
*ORGANIC synthesis

Language :: English
ISSN :: 00404039
Volume :: 53
Issue :: 21
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 74308034
Full Text :: https://doi.org/10.1016/j.tetlet.2012.03.056

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