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Super-sticky familial infections caused by Panton-Valentine leukocidin-positive ST22 community-acquired methicillin-resistant Staphylococcus aureus in Japan.
- Source :
-
Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.) . Apr2012, Vol. 18 Issue 2, p187-198. 12p. - Publication Year :
- 2012
-
Abstract
- Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which often produces Panton-Valentine leukocidin (PVL), is an emerging threat in the community. In Japan, for example, PVL-positive ST8 CA-MRSA (USA 300), which originated from the United States, persisted in families for a year and caused severe invasive infection in a child. In this study, we describe a long-term familial infection cluster caused by novel PVL-positive CA-MRSA, which most probably originated from India. This MRSA persisted in related families for more than 2 years with colonization of, for example, the nares and cheek. At least 6 of 12 members (50%) developed deep cutaneous abscesses, including recurrent and multifocal abscesses, every 1.2 months on average. All MRSA isolates from colonization and abscesses were the same, albeit with a variant in pulsed-field gel electrophoresis analysis. The MRSA exhibited the genotype ST22/ spa113(t005)/SCC mecIVa/coagulase gene ( coa) novel type and strong hemolysis activity. Moreover, the MRSA exhibited high biofilm formation (which was markedly enhanced by sub-MICs of oxacillin). Some patients were treated with levofloxacin, with successful MRSA eradication even from the whole body surface sites; however, short-term patient follow-up was not sufficient to demonstrate eradication of the familial infection cluster. The data suggest that PVL-positive novel ST22 CA-MRSA emerged in Japan, causing a long-term familial infection cluster, and that the success of ST22 CA-MRSA as both a colonizer and a pathogen could result from the combination of its strong biofilm formation and other virulence factors. A long-term patient (or carrier) follow-up is needed in the community. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1341321X
- Volume :
- 18
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.)
- Publication Type :
- Academic Journal
- Accession number :
- 74299666
- Full Text :
- https://doi.org/10.1007/s10156-011-0316-0