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Distinctive immunoregulatory effects of adenosine on T cells of older humans.
- Source :
-
FASEB Journal . Mar2012, Vol. 26 Issue 3, p1301-1310. 10p. - Publication Year :
- 2012
-
Abstract
- A role for adenosine in immunosenescence was investigated in T cells from older (≥65 yr) and younger (24-45 yr) healthy humans. Adenosine concentrations in cultures of activated T cells were significantly higher (P<0.0001) for older (145±47 nM, mean±SD) than younger (58±5.5 nM) subjects. Expression of the activation coreceptor CD28 was suppressed significantly by 0.1 to 1 µM exogenous adenosine, with greater effects of 1 µM(P<0.01) on T cells of younger (mean suppression of 67 and 65% for CD4 and CD8 T cells, respectively) than older (means of 42 and 46%) subjects. T-cell chemotaxis to CCL21 was suppressed significantly by 0.3 and 1 µM exogenous adenosine, with mean maximum decreases of 39 and 49%, respectively, for younger subjects and 28 and 31% for older subjects. Generation of IL-2 and IFN-γ by T cells of younger and older subjects was suppressed substantially only at adenosine levels of 3 µM or higher. Lower baseline expression of CD28 and chemotaxis to CCL21 and S1P for T cells from older subjects attributable to endogenous adenosine were reversed completely by two different A2A adenosine receptor antagonists without affecting T cells of younger subjects. Adenosine is an endogenous T-cell immunosuppressor in older humans, and A2A antagonists reverse adenosine-induced T-cell deficiencies of aging. [ABSTRACT FROM AUTHOR]
- Subjects :
- *IMMUNOSENESCENCE
*T cells
*LYMPHOCYTES
*ADENOSINES
*CHEMOTAXIS
Subjects
Details
- Language :
- English
- ISSN :
- 08926638
- Volume :
- 26
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- FASEB Journal
- Publication Type :
- Academic Journal
- Accession number :
- 74016454
- Full Text :
- https://doi.org/10.1096/fj.11-197046