Silencing of parathyroid hormone (PTH) receptor 1 in I cells blunts the bone anabolic activity of PTH.

Authors :: Bedi, Brahmchetna
Jau-Yi
Tawfeek, Hesham
Baek, Ki-Hyun
Adams, Jonathan
Vangara, Sameera S.
Ming-Kang Chang
Kneissei, Michaela
Neale Weitzmann, M.
Pacifici, Roberto
Source :: Proceedings of the National Academy of Sciences of the United States of America. 3/20/2012, Vol. 109 Issue 12, p4355-4356. 2p.
Publication Year :: 2012
Abstract: The article focuses on the effects of parathyroid hormone (PTH) on the bones by signaling interaction between PHT receptor 1 (PHTR1) and T cells. It states that the intermittent (iPTH) stimulates bone formation, which leads to increase bone mass. It says that the (iPTH) treatment was approved by the U.S. Food and Drug Administration for treating osteoporosis.

Subjects :: *PARATHYROID hormone
*T cells
*OSTEOPOROSIS drugs
*OSTEOPOROSIS treatment
*INTERMITTENT claudication
*HORMONE receptors

Language :: English
ISSN :: 00278424
Volume :: 109
Issue :: 12
Database :: Academic Search Index
Journal :: Proceedings of the National Academy of Sciences of the United States of America
Publication Type :: Academic Journal
Accession number :: 73945435
Full Text :: https://doi.org/10.1073/pnas.1120735109

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