IL-33/ST2 axis in innate and acquired immunity to tumors.

Authors :: Jovanovic, Ivan P.
Pejnovic, Nada N.
Radosavljevic, Gordana D.
Arsenijevic, Nebojsa N.
Lukic, Miodrag L.
Source :: OncoImmunology. Mar/Apr2012, Vol. 1 Issue 2, p229-231. 3p.
Publication Year :: 2012
Abstract: Interleukin-33, a ligand for ST2/T1, has an important role in allergy, autoimmunity and inflammation. The role of IL-33/ST2 axis in cancer is not elucidated. Using metastatic breast cancer model we provide evidence that lack of ST2 signaling led to reduced tumor growth and metastasis and enhanced anti-tumor immunity. [ABSTRACT FROM AUTHOR]