Back to Search Start Over

Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.

Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells.

Authors :
Kuzumaki, N
Suzuki, A
Narita, M
Hosoya, T
Nagasawa, A
Imai, S
Yamamizu, K
Morita, H
Nagase, H
Okada, Y
Okano, H J
Yamashita, J K
Okano, H
Suzuki, T
Source :
British Journal of Cancer. 3/13/2012, Vol. 106 Issue 6, p1148-1152. 5p. 3 Graphs.
Publication Year :
2012

Abstract

Background:It is becoming increasingly recognised that opioids are responsible for tumour growth. However, the effects of opioids on tumour growth have been controversial.Methods:The effects of κ-opioid receptor (KOR) agonist on the growth of non-small cell lung cancer (NSCLC) cells were assessed by a cell proliferation assay. Western blotting was performed to ascertain the mechanism by which treatment with KOR agonist suppresses tumour growth.Results:Addition of the selective KOR agonist U50,488H to gefitinib-sensitive (HCC827) and gefitinib-resistant (H1975) NSCLC cells produced a concentration-dependent decrease in their growth. These effects were abolished by co-treatment with the selective KOR antagonist nor-BNI. Furthermore, the growth-inhibitory effect of gefitinib in HCC827 cells was further enhanced by co-treatment with U50,488H. With regard to the inhibition of tumour growth, the addition of U50, 488H to H1975 cells produced a concentration-dependent decrease in phosphorylated-glycogen synthase kinase 3β (p-GSK3β).Conclusion:The present results showed that stimulation of KOR reduces the growth of gefitinib-resistant NSCLC cells through the activation of GSK3β. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00070920
Volume :
106
Issue :
6
Database :
Academic Search Index
Journal :
British Journal of Cancer
Publication Type :
Academic Journal
Accession number :
73279939
Full Text :
https://doi.org/10.1038/bjc.2011.574