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Skin autofluorescence is associated with severity of vascular complications in Japanese patients with Type 2 diabetes.
- Source :
-
Diabetic Medicine . Apr2012, Vol. 29 Issue 4, p492-500. 9p. 4 Charts, 1 Graph. - Publication Year :
- 2012
-
Abstract
- Diabet. Med. 29, 492-500 (2012) Abstract Aims Skin autofluorescence, a non-invasive measure of the accumulation for advanced glycation end products, has been reported to be a useful marker for diabetic vascular risks in the Caucasian population. The aim of this study was to evaluate associations between skin autofluorescence and vascular complications in non-Caucasian patients with Type 2 diabetes. Methods Subjects in this cross-sectional study comprised 130 Japanese patients with Type 2 diabetes. Skin advanced glycation end products were assessed by skin autofluorescence using an autofluorescence reader. Association between skin autofluorescence and severity of vascular complications was evaluated. Results Of the 130 patients, 60 (46.2%) had microvascular complications such as diabetic retinopathy, neuropathy and nephropathy, 10 (7.7%) had macrovascular complications and 63 (48.5%) had micro- and/or macrovascular complications. Skin autofluorescence increased with severity of vascular complications. Independent determinants of skin autofluorescence were age (β = 0.24, P < 0.01), mean HbA1c in previous year (β = 0.17, P = 0.03), microvascular complications (β = 0.44, P < 0.01) and macrovascular complications (β = 0.27, P < 0.01). Multiple logistic regression analysis revealed that diabetes duration (odds ratio 1.15, P < 0.01), systolic blood pressure (odds ratio 1.04, P = 0.01), skin autofluorescence (odds ratio 3.62, P = 0.01) and serum albumin (odds ratio 0.84, P < 0.01) were independent factors for the presence of vascular complications in these patients. Conclusions Skin autofluorescence had independent effects on vascular complications in Japanese patients with Type 2 diabetes. This indicates that skin advanced glycation end products are a surrogate marker for vascular risk and a non-invasive autofluorescence reader may be a useful tool to detect high-risk cases in non-Caucasian patients with diabetes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIAGNOSIS of diabetic neuropathies
*DIABETIC retinopathy
*ANISOTROPY
*BIOCHEMISTRY
*BLOOD pressure
*BLOOD vessels
*VASCULAR diseases
*DIABETES
*PEOPLE with diabetes
*ENDOSCOPIC surgery
*EPIDEMIOLOGY
*FLUORIMETRY
*GLYCOSYLATED hemoglobin
*HIGH density lipoproteins
*LOW density lipoproteins
*METABOLIC regulation
*TYPE 2 diabetes
*SMOKING
*STATISTICS
*DATA analysis
*ALBUMINS
*BODY mass index
*CROSS-sectional method
*DISEASE duration
*DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 07423071
- Volume :
- 29
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Diabetic Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 73176583
- Full Text :
- https://doi.org/10.1111/j.1464-5491.2011.03448.x