Multiple hypothesis testing and clustering with mixtures of non-central -distributions applied in microarray data analysis

Abstract: Multiple testing analysis and clustering methodologies are usually applied in microarray data analysis. A combination of both methods to deal with multiple comparisons among groups obtained from microarray expressions of genes is proposed. Assuming normal data, a statistic which depends on sample means and sample variances, distributed as a non-central -distribution is defined. As multiple comparisons among groups are considered, a mixture of non-central -distributions is derived. The estimation of the components of mixtures is obtained via a Bayesian approach, and the model is applied in a multiple comparison problem from a microarray experiment obtained from gorilla, bonobo and human cultured fibroblasts. [Copyright &y& Elsevier]