DNA-Based Magnetic Nanoparticle Assembly Acts as a Magnetic Relaxation Nanoswitch Allowing Screening of DNA-Cleaving Agents.

Authors :: Perez, J. Manuel
O'Loughin, Terence
Simeone, F. Joseph
Weissleder, Ralph
Josephson, Lee
Source :: Journal of the American Chemical Society. 3/27/2002, Vol. 124 Issue 12, p2856. 2p. 4 Black and White Photographs, 1 Diagram, 2 Graphs.
Publication Year :: 2002
Abstract: Focuses on the design of magnetic nanoparticle assembly acts as a magnetic relaxation switch (MRS). Detection of DNA cleaving and methylating enzymes using the MRS; Hypothesis on the effect of endonucleases; Inhibition on the effect of spin-spin relaxation time changes by the addition of oligonucleotide.

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