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Aminopyrimidinone Cdc7 Kinase Inhibitors
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Mar2012, Vol. 22 Issue 5, p1940-1943. 4p. - Publication Year :
- 2012
-
Abstract
- Abstract: We have investigated the SAR of a series of pyrimidinone-containing Cdc7 kinase inhibitors. A wide range of amine substitutions give potent compounds with activities (K i) less than 1nM. Kinase selectivity is reasonable and cytotoxicity corresponds to inhibition of MCM2 phosphorylation. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 22
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 71964633
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.01.041