Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.

Authors :: Raju, Ritesh
Piggott, Andrew M.
Khalil, Zeinab
Bernhardt, Paul V.
Capon, Robert J.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Feb2012, Vol. 53 Issue 9, p1063-1065. 3p.
Publication Year :: 2012
Abstract: Abstract: Chemical analysis of a marine-derived Streptomyces sp. (CMB-M0392) isolated from sediment collected off Heron Island, Queensland, Australia, yielded a new benzothiazine ansamycin, heronamycin A. The absolute stereostructure of heronamycin A was determined by detailed spectroscopic analysis and X-ray crystallography. Heronamycin A exhibited modest antimicrobial activity against Bacillus subtilis strains ATCC 6051 and 6633 (IC50 =18 and 14μM, respectively). [Copyright &y& Elsevier]

Subjects :: *ANSAMYCINS
*BENZOTHIAZINE
*STREPTOMYCES
*MARINE bacteria
*SEDIMENTS
*X-ray crystallography

Language :: English
ISSN :: 00404039
Volume :: 53
Issue :: 9
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 71483391
Full Text :: https://doi.org/10.1016/j.tetlet.2011.12.064

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