Back to Search
Start Over
Does long-acting injectable risperidone make a difference to the real-life treatment of schizophrenia? Results of the Cohort for the General study of Schizophrenia (CGS)
- Source :
-
Schizophrenia Research . Feb2012, Vol. 134 Issue 2/3, p187-194. 8p. - Publication Year :
- 2012
-
Abstract
- Abstract: Objective: The primary aim of this study was to compare the impact of risperidone long-acting injectable (R-LAI) to other antipsychotics on rates of hospitalisation in real-life settings. Method: The Cohort for the General study of Schizophrenia (CGS) followed 1859 patients diagnosed with schizophrenia (DSM-IV) from 177 psychiatric wards of public and private hospitals across France over a mean period of 12months. These patients were ambulatory or had been hospitalised for less than 93days at study entry. Recruitment was stratified for long-acting second-generation antipsychotic use. A multivariate Poisson regression adjusted for confounding with propensity scores and allowing for autocorrelation was used for the calculation of relative rates of hospitalisation with 95% confidence intervals. Results: The mean age of participants was 37.65years, 68.3% were male and 36.7% were hospitalised for less than 93days at study entry. Altogether, participants accumulated 796 hospital stays (53.4 per 100 person-years). R-LAI patients were slightly younger and had been hospitalised more often in the past 12months compared to non-R-LAI users. The adjusted Poisson regression analysis showed R-LAI use to be associated with a lower rate of future hospitalisation: 0.66 [0.46–0.96] compared to non-R-LAI use, and 0.53 [0.32–0.88] compared to use of other LAIs. Conclusion: Use of R-LAI was associated with lower rates of hospitalisation compared to non-use of R-LAI. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09209964
- Volume :
- 134
- Issue :
- 2/3
- Database :
- Academic Search Index
- Journal :
- Schizophrenia Research
- Publication Type :
- Academic Journal
- Accession number :
- 71335622
- Full Text :
- https://doi.org/10.1016/j.schres.2011.10.022