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Clinical Course and the Role of Shiga Toxin-Producing Escherichia coli Infection in the Hemolytic-Uremic Syndrome in Pediatric Patients, 1997-2000, in Germany and Austria: A Prospective Study.
- Source :
-
Journal of Infectious Diseases . 8/15/2002, Vol. 186 Issue 4, p493. 8p. - Publication Year :
- 2002
-
Abstract
- Hemolytic-uremic syndrome (HUS) is mainly associated with foodborne infections by Shiga toxin-producing Escherichia coli (STEC). From January 1997 through December 2000, 394 children with HUS were evaluated in a prospective multicenter surveillance study in Germany and Austria (incidences, 0.7/100,000 and 0.4/100,000 children <15 years old, respectively). Blood leukocytosis was associated with increased detection of STEC in stool cultures (P .01) and a more severe disease course. Risk of death was associated with cerebral involvement (P < .01). Most strikingly, non-O157:H7 STEC were detected in 43% of stool cultures of patients with HUS: 026 was detected in 15%, sorbitol-fermenting O157:H- in 10%, O145 in 9%, O103 in 3%, and O111 in 43%. Patients with O157:H7 serotypes required dialysis for a longer time and had bloody diarrhea detected more frequently, compared with patients with nonO157:H7 serotypes (P < .05). This large study in children with HUS underlines the rising importance of non-O157:H7 serotypes, and, despite increased public awareness, the number of patients remained unchanged. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ESCHERICHIA coli
*HEMOLYTIC-uremic syndrome
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 186
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 7124306
- Full Text :
- https://doi.org/10.1086/341940