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Synthesis of novel cinnamanilides as potential immunosuppressive agents
- Source :
-
European Journal of Medicinal Chemistry . Jan2012, Vol. 47, p585-593. 9p. - Publication Year :
- 2012
-
Abstract
- Abstract: A series of new cinnamanilides (6–40) were synthesized and their immunosuppressive activity and cytotoxicity were evaluated. Most of the cinnamanilides showed good immunosuppressive activity. Among the synthesized compounds, (Z)-N-(4-bromophenyl)-2-methoxy-3-(4-methoxyphenyl)acrylamide (37) and (Z)-2-methoxy-3-(4-methoxyphenyl)-N-p-tolylacrylamide (38) exhibited potent immunosuppressive activity (IC50 = 1.77 ± 0.33 and 0.94 ± 0.13 μM) without significant cytotoxicity. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 02235234
- Volume :
- 47
- Database :
- Academic Search Index
- Journal :
- European Journal of Medicinal Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 70906167
- Full Text :
- https://doi.org/10.1016/j.ejmech.2011.10.027