Back to Search Start Over

Synthesis of novel cinnamanilides as potential immunosuppressive agents

Authors :
Shi, Lei
Wang, Lu
Wang, Zhi
Zhu, Hai-Liang
Song, Qiao
Source :
European Journal of Medicinal Chemistry. Jan2012, Vol. 47, p585-593. 9p.
Publication Year :
2012

Abstract

Abstract: A series of new cinnamanilides (6–40) were synthesized and their immunosuppressive activity and cytotoxicity were evaluated. Most of the cinnamanilides showed good immunosuppressive activity. Among the synthesized compounds, (Z)-N-(4-bromophenyl)-2-methoxy-3-(4-methoxyphenyl)acrylamide (37) and (Z)-2-methoxy-3-(4-methoxyphenyl)-N-p-tolylacrylamide (38) exhibited potent immunosuppressive activity (IC50 = 1.77 ± 0.33 and 0.94 ± 0.13 μM) without significant cytotoxicity. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
02235234
Volume :
47
Database :
Academic Search Index
Journal :
European Journal of Medicinal Chemistry
Publication Type :
Academic Journal
Accession number :
70906167
Full Text :
https://doi.org/10.1016/j.ejmech.2011.10.027