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ING Genes Work as Tumor Suppressor Genes in the Carcinogenesis of Head and Neck Squamous Cell Carcinoma.

Authors :
Xiaohan Li
Kikuchi, Keiji
Takano, Yasuo
Source :
Journal of Oncology. 2011, p1-11. 11p.
Publication Year :
2011

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world. The evolution and progression of HNSCC are considered to result from multiple stepwise alterations of cellular and molecular pathways in squamous epithelium. Recently, inhibitor of growth gene (ING) family consisting of five genes, ING1 to ING5, was identified as a new tumor suppressor gene family that was implicated in the downregulation of cell cycle and chromatin remodeling. In contrast, it has been shown that ING1 and ING2 play an oncogenic role in some cancers, this situation being similar to TGF-β. In HNSCC, the ING family has been reported to be downregulated, and ING translocation from the nucleus to the cytoplasm may be a critical event for carcinogenesis. In this paper, we describe our recent results and briefly summarize current knowledge regarding the biologic functions of ING in HNSCC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16878450
Database :
Academic Search Index
Journal :
Journal of Oncology
Publication Type :
Academic Journal
Accession number :
70866510
Full Text :
https://doi.org/10.1155/2011/963614