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Lipid Mediators and Human Leukemic Blasts.
- Source :
-
Journal of Oncology . 2011, p1-7. 7p. - Publication Year :
- 2011
-
Abstract
- Some of the most potent inflammatory mediators share a lipid origin. They regulate a wide spectrum of cellular processes including cell proliferation and apoptosis. However, the precise roles and ways (if any) in which these compounds impact the growth and apoptosis of leukemic blasts remain incompletely resolved. In spite of this, significant advances have been recently made. Here we briefly review the current knowledge about the production of lipid mediators (prostaglandins, leukotrienes, plateletactivating factor) by leukemic blasts, the enzymatic activities (phospholipase A2, cyclooxygenases, lipoxygenases) involved in their productions and their effects (through specific membrane bound receptors) on the growth, and apoptosis of leukemic blasts. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL proliferation
*APOPTOSIS
*PROSTAGLANDINS
*CYCLOOXYGENASES
*LIPOXYGENASES
Subjects
Details
- Language :
- English
- ISSN :
- 16878450
- Database :
- Academic Search Index
- Journal :
- Journal of Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 70866460
- Full Text :
- https://doi.org/10.1155/2011/389021