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Amplification of Screening Sensitivity through Selective Destruction: Theory and Screening of a Library of Carbonic Anhydrase Inhibitors.
- Source :
-
Journal of the American Chemical Society . 5/22/2002, Vol. 124 Issue 20, p5692. 10p. 6 Diagrams, 1 Chart, 11 Graphs. - Publication Year :
- 2002
-
Abstract
- Assesses the screening method for the identification of enzyme inhibitors. Advantages of dynamic combinatorial chemistry; Suppression of carbonic anhydrase activity by sulfonamide dipeptides; Degradation of the poor inhibitors by enzymes.
- Subjects :
- *COMBINATORIAL chemistry
*ENZYME inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 00027863
- Volume :
- 124
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 7060041
- Full Text :
- https://doi.org/10.1021/ja017099+