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Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program.
- Source :
-
Diabetes Care . Feb2012, Vol. 35 Issue 2, p363-366. 4p. 1 Chart. - Publication Year :
- 2012
-
Abstract
- OBJECTIVE--We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss--inducing interventions (lifestyle and metformin) versus placebo. RESEARCH DESIGN AND METHODS--Sixteen obesity-predisposing single nucleotide polymorphisms (SNPs) were tested for association with short-term (baseline to 6 months) and long-term (baseline to 2 years) weight loss and weight regain (6 months to study end). RESULTS--Irrespective of treatment, the Ala12 allele at PPARG associated with short- and long-term weight loss (20.63 and 20.93 kg/allele, P ≤ 0.005, respectively). Gene-treatment interactions were observed for short-term (LYPLAL1 rs2605100, Plifestyle*SNP = 0.032; GNPDA2 rs10938397, Plifestyle*SNP = 0.016; MTCH2 rs10838738, Plifestyle*SNP = 0.022) and long-term (NEGR1 rs2815752, Pmetformin*SNP = 0.028; FTO rs9939609, Plifestyle*SNP = 0.044) weight loss. Three of 16 SNPs were associated with weight regain (NEGR1 rs2815752, BDNF rs6265, PPARG rs1801282), irrespective of treatment. TMEM18 rs6548238 and KTCD15 rs29941 showed treatment-specific effects (Plifestyle*SNP < 0.05). CONCLUSIONS--Genetic information may help identify people who require additional support to maintain reduced weight after clinical intervention. [ABSTRACT FROM AUTHOR]
- Subjects :
- *WEIGHT loss
*WEIGHT gain
*LIFESTYLES
*METFORMIN
*DIABETES prevention
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 35
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 70555430
- Full Text :
- https://doi.org/10.2337/dc11-1328