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Appraisal of Antihyperlipidemic Activities of Lentinus lepideus in Hypercholesterolemic Rats.
- Source :
-
Mycobiology . Dec2011, Vol. 39 Issue 4, p283-289. 7p. 2 Black and White Photographs, 2 Charts, 2 Graphs. - Publication Year :
- 2011
-
Abstract
- The wild edible mushroom, Lentinus lepideus has recently been cultivated for commercial use in Korea. While the mushroom has been widely used for nutritional and medicinal purposes, the possible anti-hyperlipidemic action is unclear. The effects of dietary L. lepideus on plasma and feces biochemical and on the liver histological status were investigated in hypercholesterolemic rats. Six-wk-old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Biochemical and histological examinations were performed. A diet containing 5% L. lepideus fruiting bodies reduced plasma total cholesterol, triglyceride, low-density lipoprotein, total lipid, phospholipids, and the ratio of low-density to high-density lipoprotein. Body weight was reduced. The diet did not adversely affect plasma biochemical and enzyme profiles. L. lepideus reduced significantly plasma β- and pre-β-lipoprotein, while α-lipoprotein content was increased. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red O staining revealed normal findings for mushroom-fed hypercholesterolemic rats. The present study suggests that a diet supplemented with L. lepideus can provide health benefits by acting on the atherogenic lipid profile in hypercholesterolemic rats. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GEL electrophoresis
*LENTINUS
*MUSHROOMS
*HISTOPATHOLOGY
*LIPIDS
Subjects
Details
- Language :
- English
- ISSN :
- 12298093
- Volume :
- 39
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Mycobiology
- Publication Type :
- Academic Journal
- Accession number :
- 70496987
- Full Text :
- https://doi.org/10.5941/MYCO.2011.39.4.283