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Identification of two new alleles in a single Korean individual, HLA-B*1568 and HLA-DRB1*1208.
- Source :
-
Tissue Antigens . May2002, Vol. 59 Issue 5, p430-432. 3p. - Publication Year :
- 2002
-
Abstract
- We have identified a new HLA-B*15 allele and a new HLA-DRB1*12 allele, named B*1568 and DRB1*1208, respectively. The alleles were identified using a combination of sequence specific primers, reverse line sequence specific oligonucleotide probing and sequence-based typing. Both alleles were identified in a single individual of Korean origin. HLA-B*1568 appears to be an HLA-B*4801/B*1507 hybrid combining the exon 2 sequence of B*4801 and the exon 3 and 4 sequences of B*1507. Exon 2 of DRB1*1208 was most similar to DRB1*1201 or 1206, with a single mismatch at nucleotide position 165 (A to C). At the protein level, this substitution results in a phenylalanine substitution at position 26 that creates an identical amino acid sequence to DRB3*0202 between amino acid positions 17 and 36. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HLA histocompatibility antigens
*KOREANS
*GENETICS
Subjects
Details
- Language :
- English
- ISSN :
- 00012815
- Volume :
- 59
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Tissue Antigens
- Publication Type :
- Academic Journal
- Accession number :
- 7048790
- Full Text :
- https://doi.org/10.1034/j.1399-0039.2002.590513.x