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Average Cost-Effectiveness Ratio with Censored Data.
- Source :
-
Journal of Biopharmaceutical Statistics . Mar/Apr2012, Vol. 22 Issue 2, p401-415. 15p. - Publication Year :
- 2012
-
Abstract
- In cost-effectiveness analysis, interest could lie foremost in the incremental cost-effectiveness ratio (ICER), which is the ratio of the incremental cost to the incremental benefit of two competing interventions. The average cost-effectiveness ratio (ACER) is the ratio of the cost to benefit of an intervention without reference to a comparator. A vast literature is available for statistical inference of the ICERs, but limited methods have been developed for the ACERs, particularly in the presence of censoring. Censoring is a common feature in prospective studies, and valid analyses should properly adjust for censoring in cost as well as in effectiveness. In this article, we propose statistical methods for constructing a confidence interval for the ACER from censored data. Different methods—Fieller, Taylor, bootstrap—are proposed, and through simulation studies and data analysis, we address the performance characteristics of these methods. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10543406
- Volume :
- 22
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Biopharmaceutical Statistics
- Publication Type :
- Academic Journal
- Accession number :
- 70383925
- Full Text :
- https://doi.org/10.1080/10543406.2010.544437