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Intrapleural Chemo- and Hyperthermotherapies for Malignant Pleural Effusion: A Randomized Prospective Study.
- Source :
-
Cancer Investigation . Feb2012, Vol. 30 Issue 2, p126-130. 5p. - Publication Year :
- 2012
-
Abstract
- Objective: The current prospective randomized study was designed to evaluate the safety and efficacy of combined intrapleural cisplatin and OK-432 (picibanil) plus hyperthermotherapy in patients with malignant pleural effusion (MPE). Methods: A total of 358 patients with MPE due to end-stage malignancies were enrolled and randomly divided into two groups, A and B: the intrapleural combination of cisplatin and OK-432 with hyperthermotherapy (n == 179) or without hyperthermotherapy (n == 179), respectively. Mild toxicities such as nausea, vomiting or anorexia, bone marrow depression, and pyrexia were similar in both groups. Result: Patients in Group A (with hyperthermotherapy) showed a significantly higher overall response (93.4%%) compared to those in Group B (79.8%%, χ2 == 43.11, p < .05). The median survival time for patients in Group A and Group B were 8.9 and 6.2 months, respectively ( p > .05). After treatment, the quality of life scores were significantly increased in both groups as compared to prior treatment ( p < .05). Conclusion: In conclusion, our study suggests that combined intrapleural cisplatin and OK-432 followed by hyperthermotherapy are more effective in the control of MPE and improve patients' quality of life. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 30
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 70359311
- Full Text :
- https://doi.org/10.3109/07357907.2011.633292