NeŽádoucí reakce při odbĚru hemopoetických kmenových bunĚk u nepříbuzných dárců - desetiletá zkučenost Českého národního registru dárců dřenĚ (ČNRDD).

We analyzed retrospectively a group of 339 unrelated donors who underwent bone marrow (n=169) or peripheral stem cell (n=170) collection in the years 1999-2009. The required doses of haematopoietic stem cells were collected in 60 % of procedures, with no significant difference between men and women. Suboptimal grafts were obtained in 2 % of bone marrow collections and 5 % of peripheral blood stem cell collections. The frequency of adverse events was 55 % (51 % of bone marrow and 59 % of peripheral blood stem cell collections). Nausea and vomiting following general anaesthesia and pain at the aspiration site were the most common reactions in bone marrow donors. Peripheral blood stem cell collections were most frequently associated with leukopenia and thrombocytopenia. A higher incidence of adverse events was observed in women. Neither severe adverse events nor donor death associated with the collection were recorded during the observed period. The study demonstrated that the collection of haematopoietic stem cells from healthy donors is a safe procedure with a low risk of complications. The donor registry has established standard procedures for donor selection, for examinations to be conducted before collection as well as for the process of caring for donors during collection. Compliance with these rules in combination with the high professionalism of all participating health care personnel decreases the probability of severe or unexpected complications during donation. [ABSTRACT FROM AUTHOR]