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Human adjuvant disease induced by foreign substances: a new model of ASIA (Shoenfeld's syndrome).
- Source :
-
Lupus . Feb2012, Vol. 21 Issue 2, p128-135. 8p. 4 Color Photographs, 1 Black and White Photograph, 4 Charts. - Publication Year :
- 2012
-
Abstract
- Objective: To investigate the clinical, laboratory and histological manifestations of patients who received illegal injections of foreign substances for cosmetic purposes.Patients and methods: We studied patients who met the following inclusion criteria: 1) history of application of foreign substances for cosmetic purposes, 2) clinical data of autoimmune disease or non-specific autoimmune manifestation (i.e. arthralgias, myalgia, malaise, fever, and weight loss), 3) detection of autoantibodies in patients’ sera, 4) histological evidence of chronic inflammation and/or granulomatous reaction to foreign body.Results: Fifty female patients aged 44.4 ± 10 years were studied. The mean time between application of foreign substances and onset of symptoms was 4.5 ± 4.3 years. Patients were followed for 12 ± 7.5 years. Forty-one patients were injected with mineral oil, nine patients received other substances: three iodine gadital, one guayacol, one guayacol plus silicone fluid, two collagen, two silicone fluid. The sites of application were: buttocks (36), legs and/or thighs (11), breasts (eight) hands and face (one), face (two) (seven patients received an injection to more than one site). Thirty patients presented with non-specific autoimmune manifestations, whereas 20 patients fulfilled the criteria for a defined autoimmune disease such as systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, overlap syndrome, autoimmune hemolytic anemia, autoimmune thyroiditis, autoimmune hepatitis, and ulcerative colitis.Conclusions: Cases of human adjuvant disease following illegal injections of oil substances for cosmetic purposes are reported. Patients presented with defined autoimmune diseases as well as with non-specific autoimmune manifestations. Illegal injection of these substances could lead to serious local and systemic complications, even to death. These cases represent another model of Autoimmune/inflammatory Syndrome Induced by Adjuvants (ASIA). The use of these substances should be prohibited. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 09612033
- Volume :
- 21
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Lupus
- Publication Type :
- Academic Journal
- Accession number :
- 70235909
- Full Text :
- https://doi.org/10.1177/0961203311429317