Back to Search Start Over

Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages

Authors :
Hwang, Ji Sang
Lee, Seon A
Hong, Seong Su
Han, Xiang Hua
Lee, Chul
Lee, Dongho
Lee, Chong-Kil
Hong, Jin Tae
Kim, Youngsoo
Lee, Mi Kyeong
Hwang, Bang Yeon
Source :
Bioorganic & Medicinal Chemistry Letters. Jan2012, Vol. 22 Issue 1, p706-708. 3p.
Publication Year :
2012

Abstract

Abstract: The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC50 values of 4.6–21.6μM. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0960894X
Volume :
22
Issue :
1
Database :
Academic Search Index
Journal :
Bioorganic & Medicinal Chemistry Letters
Publication Type :
Academic Journal
Accession number :
70157080
Full Text :
https://doi.org/10.1016/j.bmcl.2011.10.043