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Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.
- Source :
-
Nature Genetics . Jan2012, Vol. 44 Issue 1, p58-61. 4p. 1 Chart, 1 Graph. - Publication Year :
- 2012
-
Abstract
- To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10?9) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10?15). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10?7). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 44
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 70077101
- Full Text :
- https://doi.org/10.1038/ng.993