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Age and gender may affect posterior reversible encephalopathy syndrome in renal disease.
- Source :
-
Pediatric Nephrology . Feb2012, Vol. 27 Issue 2, p277-283. 7p. 1 Black and White Photograph, 4 Charts. - Publication Year :
- 2012
-
Abstract
- It remains elusive what factors affect posterior reversible encephalopathy syndrome (PRES). Eleven PRES children, all with acute glomerulonephritis, Alport syndrome, and lupus nephritis, 5 with nephrosis, and 3 renal transplant recipients, were studied. PRES recurred in 1 patient. Neurological symptoms were graded as 1: mild (headache, nausea/vomiting, or tremor), 2: moderate (vision change), and 3: severe (mental dysfunction, cerebellar symptoms, seizures, recurrence of seizures, and coma). Magnetic resonance imaging was graded as 1: subtle change, 2: abnormal large areas, and 3: complete involvement of the regions. The common symptoms were seizures (100%), headache (82%), nausea/vomiting (73%), coma (55%), and vision change (46%). Seizures recurred in 7 (64%). All but one (91%) developed hypertension and 7 (64%) received calcineurin inhibitors (CNI). Edema occurred in 7 (64%) and renal insufficiency/end-stage renal disease (ESRD) in 4 (36%). Seizures recurred frequently in younger patients. Symptoms were severe in girls. Duration or severity of the condition with predisposing factors (hypertension, CNI, nephrosis or renal insufficiency/ERSD) did not make a difference in the symptoms and neuroimaging. Two patients developed chronic epilepsy. Age and gender may affect PRES symptoms. Our results are limited by small sample size and should be determined using larger numbers of patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ADRENOCORTICAL hormones
*HORMONE therapy
*ANTI-inflammatory agents
*TREATMENT of chronic kidney failure
*CYCLOSPORINE
*MACROLIDE antibiotics
*HYDROLASES
*ALBUMINS
*AGE distribution
*CHRONIC kidney failure
*SEIZURES (Medicine)
*FISHER exact test
*GLOMERULONEPHRITIS
*HEADACHE
*HEMODIALYSIS
*HYPERTENSION
*KIDNEY transplantation
*LONGITUDINAL method
*MAGNETIC resonance imaging
*NEUROLOGIC manifestations of general diseases
*HEALTH outcome assessment
*SEX distribution
*SPASMS
*STATISTICS
*U-statistics
*LUPUS nephritis
*DISEASE relapse
*DATA analysis
*TREATMENT effectiveness
*RETROSPECTIVE studies
*POSTERIOR leukoencephalopathy syndrome
*DATA analysis software
*NEPHRITIS
*DESCRIPTIVE statistics
*SYMPTOMS
*GENETICS
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 27
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 70068608
- Full Text :
- https://doi.org/10.1007/s00467-011-1974-y