EFECTO DE LA RECUPERACION NUTRICIONAL EN LAS , CONCENTRACIONES SERICAS DE OXIDO NiTRICO, MALONALDEHiDO Y TNF ALFA EN EL NINO DESNUTRIDO GRAVE.

Introduction: Alterations involving antioxidant respon e and immunological competence are consequences of malnutrition. The aim of this study is to assess the effect of nutritional recovery on serum concentrations of nitric oxide (NO). malonaldehyde (MDA) and TN Fa in the severely malnourished child. Methods: 47 children were prospectively studied (2 months to 8 years old): 27 children with mixed type severe malnutrition and 20 controls who attended the Department of Education and Nutritional Recovery at the Chiquinquin\ Hospital in Maracaibo-Venezuela. NO and the MDA were detennined by Diazotization trial and derivatives of the barbituric acid respectively; TN F-a was assessed by the ELISA technique. Results: 0 and MDA concentrations showed no significant difference with controls, although there was a significant decrease with respect to pre-treatment values (p :5 0,0001 for NO and p :5 0.00 1 for MDA Values for TNF-a were significantly different from controls and pre-treatment values (p< 0,000 I ). Conclusions: utritional recovery therapy affects the decrease in serum concentrations of 0, M DA and TNF-a, probably due to the supplementation of vitamins and tmcronutrients during this treatment [ABSTRACT FROM AUTHOR]