Malignite şüpheli veya foliküler tiroid lezyonlarında Tc99m sestamibi görüntüleme.

Objective: In this study we evaluated the usefullness of Tc99msestamibi, a tumor agent, to detect malignancy for nodules reported as "SFM" and "ITFL". Methods: Thirteen of 24 cases, reported as "SFM" or "ITFL" by FNAB, underwent bilateral total thyroidectomy after imaging by Tc99msestamibi. Then, Tc99msestamibi imaging, FNAB and hystopathologic results were compared. Results: There were only one male and the mean age was 44,9±12,6 (29-77). We detected "SFM" in 10 (76,9%) cases, and "TFL" in 3 (23,1%) cases. By hystopathologic investigation 6 papillary, 1 follicular, 1 medullary, 4 benign cystic goiter and 1 lymhocytic thyroiditis detected. There was MIBI uptake in all cases with malignancy, except one with medullary thyroid cancer (6 papillary and one follicular cancer). MIBI uptake was detected also in one of four cases with benign cystic gioter and one case with lynphocytic goiter. The mean nodule diameter was 26,9±20,1 mm (23,6±6.87 mm in benign cases, 29,28±26,45 mm in malignant cases, p>0.05). Conclusion: The sensitivity, specifity, pozitive and negative predictive value of of Tc99msestamibi were 75% and 60%, 0,75 ve 0,60, respectively. As conclusion, to determine the usefulness of Tc99msestamibi for detecting malignancy in nodules reported as "SFM" or "ITFL" by FNAB, more studies with larger populations should be performed. [ABSTRACT FROM AUTHOR]