Channel Openings Are Necessary but not Sufficient for Use-dependent Block of cardiac Na+ Channels by Flecainide: Evidence from the Analysis of Disease-linked Mutations.

Presents a study that determined what disease-modified channel properties underlie distinct responses to the sodium ion (Na[sup+]) channel blocker flecainide in Brugada syndrome (BrS) and LQT-3, a variant of the Long QT syndrome mutations. Analysis of the molecular determinants of flecainide block; Influence of inherited mutations on the voltage dependence of flecainide use-dependent block; Impact of flecainide on Na[sup+] channel availability.