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Sesquiterpenoids and norterpenoids from Vitex negundo
- Source :
-
Fitoterapia . Jan2012, Vol. 83 Issue 1, p49-54. 6p. - Publication Year :
- 2012
-
Abstract
- Abstract: Chemical investigation on the seeds of Vitex negundo has afforded a new furan-containing sesquiterpenoid, negunfurol (1), a new norlabdane-type diterpenoid, negundoal (2), and two new norursane-type triterpenoids, negundonorins A (3) and B (4), together with two know compounds, 3-formyl-4,5-dimethyl-8-oxo-5H-6,7-dihydronaphtho[2,3-b]furan (5) and 3-epi-corosolic acid (6). Their structures and configurations were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. Compound 3 was strongly cytotoxic against ZR-75-30 cell line with IC50 value of 0.56±0.19μg/mL, whereas compound 1 was most active against HL-60 cell line with IC50 value of 0.94±0.26μg/mL. [Copyright &y& Elsevier]
- Subjects :
- *ALTERNATIVE medicine
*ANALYSIS of variance
*ANTINEOPLASTIC agents
*BIOLOGICAL models
*BIOPHYSICS
*DOSE-effect relationship in pharmacology
*MASS spectrometry
*RESEARCH methodology
*MEDICINAL plants
*NUCLEAR magnetic resonance spectroscopy
*SEEDS
*SPECTRUM analysis
*PLANT extracts
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 83
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 69738705
- Full Text :
- https://doi.org/10.1016/j.fitote.2011.09.012