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Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry: what is Lennert's lymphoma nowadays?
- Source :
-
Histopathology . Dec2011, Vol. 59 Issue 6, p1173-1182. 10p. 2 Color Photographs, 1 Diagram, 3 Charts. - Publication Year :
- 2011
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Abstract
- Hartmann S, Agostinelli C, Klapper W, Korkolopoulou P, Koch K, Marafioti T, Piccaluga P P, Patsouris E, Pileri S & Hansmann M-L (2011) Histopathology 59, 1173-1182 Revising the historical collection of epithelioid cell-rich lymphomas of the Kiel Lymph Node Registry: what is Lennert's lymphoma nowadays? Aims: Lennert's lymphoma is a rare variant of peripheral T-cell lymphoma (PTCL) not otherwise specified (NOS). The aim of this study was to further characterize this tumour. Methods and results: Historical material of 97 lymphomas with a high content of epithelioid cells, collected at the Kiel Lymph Node Registry were reviewed, by applying immunohistochemistry and current diagnostic criteria. Among all cases revised, various B-cell lymphoma entities (25 cases), Hodgkin lymphomas (21 cases) and PTCL subtypes (48 cases) could be identified. A distinctive subgroup of eight PTCLs was found that were regarded as genuine Lennert's lymphomas. These cases were characterized by mild atypia, a non-activated cytotoxic phenotype [TIA1 cytotoxic granule-associated RNA binding protein (TIA1)-positive+ and granzyme B-negative], and a substantial lack of follicular T-helper (TFH) cell markers. Among the other PTCLs, including angioimmunoblastic T-cell lymphoma and PTCL NOS, many cases with positivity for more than three TFH cell-associated molecules were recorded. Conclusions: Our study shows that, according to current criteria, Lennert's lymphoma is a rare but distinctive entity among epithelioid cell-rich lymphomas, differing on grounds of morphology and immunophenotype from other PTCL subtypes. An additional finding is the broad morphological spectrum of epithelioid-cell rich PTCLs showing a TFH cell phenotype. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LYMPHOMAS
*HODGKIN'S disease
*LYMPH nodes
*T cells
*PHENOTYPES
*CARRIER proteins
*RNA
Subjects
Details
- Language :
- English
- ISSN :
- 03090167
- Volume :
- 59
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 69733869
- Full Text :
- https://doi.org/10.1111/j.1365-2559.2011.04069.x