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Effort toward the single pot synthesis of 6-(Biphenyl-4-yl)-2-[2-(indol-1-yl)ethyl]-4,5-dihydropyridazin-3(2H)-one from 6-(Biphenyl-4-yl)-2-[2-(indol-1-yl)ethyl]-4,5-dihydropyridazin-3(2H)-one.

Authors :
Asif, Mohammad
Singh, Anita
Lakshmayya
Source :
Journal of Pharmaceutical Negative Results. 2011, Vol. 2 Issue 2, p69-72. 4p.
Publication Year :
2011

Abstract

Background: Many synthetic heterocyclic compounds are known to have different biological activities. Pyridazine and its derivatives are the important six membered heterocyclic compounds containing two N-hetero atoms. The pyridazine moiety is an important structural feature of many biologically active compounds. Pyridazine derivatives show diverse pharmacological properties. Aims and Objectives of the Study: The goal of this study, Pyridazine hold considerable interest relative to the preparation of organic intermediates and physiologically active compounds also. On the basis of its important in reported literature, we synthesized the 6-(Biphenyl-4-yl)-2-[2-(indol- 1-yl)ethyl]-4,5-dihydropyridazin-3(2H)-one from 6-(Biphenyl-4-yl)-2-[2-(indol-1-yl) ethyl]-4,5-dihydro pyridazin-3(2H)-one in single step or pot reaction. Results: The important Observations and concrete implications of the study. The result showed that the compound 6-(Biphenyl-4-yl)-2-[2-(indol-1-yl) ethyl]-4,5-dihydropyridazin-3(2H)- one was not prepared by this method. The synthesis of compound has been confirmed by the spectral analysis namely IR, 1H NMR and Mass spectroscopy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09769234
Volume :
2
Issue :
2
Database :
Academic Search Index
Journal :
Journal of Pharmaceutical Negative Results
Publication Type :
Academic Journal
Accession number :
69597788
Full Text :
https://doi.org/10.4103/0976-9234.90215